婴幼儿至青少年骨密度正常参考值的研究

Normal reference values for bone mineral density in infants,young children and abolescents aged 1-18 years

目的:提供安康市婴幼儿至青少年尺骨、桡骨骨密度的正常参考值,服务于临床及科研应用。方法:使用双能X线骨密度仪测量安康市600名1～18岁婴幼儿至青少年尺骨、桡骨骨密度,并与国外同类研究进行比较。结果:骨矿化过程在儿童期为渐进形式,在青春期呈现加速趋势,在尺骨、桡骨各部位及身体的各个发育阶段都存在着显著的性别及年龄差异。尽管骨的发育因躯体部位、性别及尺寸大小而异,但是女性在10～15岁年龄段倾向于尺骨、桡骨的骨密度高于同年龄段男性,而自16岁以后则男性尺骨、桡骨的骨密度高于女性。部份原因是女性骨矿化增长加速过程发动时序早于男性。与白种儿童相比较,这些安康市受试对象尺骨、桡骨的骨密度较低。结论:骨的发育因性别、年龄、部位及种族而呈现不同规律,在评价时应予以考虑。

Objective：The paper aims to provide normal values for the assessment of bone status in infants, young children and abolescents to serve clinical as well as research purposes. Methods： Normal values of hone mineral density for Ulna, radius were de- rived from measurements on 600 infants, young children and abolescents 1 to 18 years from An-kang city. BMD was determined by du- al-energy x-ray absorptiometry （DEXA）. Results： Bone mineralization increased gradually in early child hood and accelerated during adolescence and there were significant age and gender effects on relative regions of Ulna, radius as well as on relative developmental stages of body. Although development of bone was heterogeneous in term of localization, sex and magnitude,it seems re-males had a higher BMD of Ulna, radius than their counterparts between the ages of 10 and 15years,from age 16 years,it is quiet on the contrary. Parts of reasons were due to females earlier outset of acceleration for increase on BMD. Compared with white-origin children, the sub- jects were bestowed with less BMD. Conclusions： The development of bone depends on sex, age, region and race. Considerations should be taken when normal values were applied to assess bone status.