高血压患者年龄和病程及动脉硬化指数与尿微量白蛋白的相关性

The correlation of age,disease course and ambulatory arterial stiffness index arterial stiffness index with UmAlb

目的:探讨高血压患者年龄、病程及动态动脉硬化指数(AASI)与尿微量白蛋白(UmAIb)的关系。方法:将2008年至2010年广东药学院附属第一医院收治的108例原发性高血压患者,按年龄、病程及AASI分组,检测不同组别患者的UmAIb浓度,分析年龄、病程及AASI与UmAIb的关系。结果:不同年龄、病程、AASI组间患者UmAIb比较,差异有统计学意义(F=32.83、59.18、t=7.85,P<0.001);相关分析结果显示,年龄、病程及AASI与UmAIb呈正相关(r=0.7906、、0.7490、0.6999,P<0.001)。偏相关分析结果表明,年龄、病程及AASI与UmAlb的相关系数均变小,≥60岁患者的AASI与UmAlb相关性无统计学意义(r=0.088,P=0.638)。结论:UmAlb随年龄及病程的增加而增加,AASI是预测高血压患者早期肾脏损害的有用指标。

Objective： To investigate the correlation of age, disease course and ambulatory arterial stiffness index （AASI） with UmAlb. Methods：Between 2008 and 2010,108 patients with primary hypertension registered in the First Affiliated Hospital of Guangdong Pharmaceutical University were divided into groups according to age, disease course and detected their UmAlb concentrations of patients in different group. Thereafter, the correlation of age, disease course and AASI with UmAlb was analyzed. Results：The UmAlb concentrations were different groups with different age, disease course and AASI （F = 32. 83,59. 18,t = 7.85, P 〈 0. 001 ）. The relative analysis outcome showed a positive correlation of age, disease course and AASI with UmAlb （ r = 0. 7906,0. 7490, 0. 6999 ,P 〈 0.001 ）. Partial correlation analysis outcome demonstrated that the correlation indexes between age, disease course, AASI and UmAlb became smaller. Notably, no difference was found in the correlation of AASI and UmAIb between patients ≥60 years old and the other patients （ r = 0.088, P = 0. 638 ）. Conclusion： The UmAlb concentration increased along with the increase of age and disease course. AASI was the useful indicator for prediction of early renal injury in patients with hypertension.