有创机械通气对突发致死性哮喘疗效的影响

Effects of invasive mechanical ventiation on sudden-onset fatal asthma

目的:探讨有创机械通气对突发致死性哮喘(SFA)治疗效果的影响。方法:回顾性分析2001年1月至2011年12月广东省梅州市丰顺县人民医院收治的42例SFA患者的临床资料,根据治疗方式不同分非机械通气组(27例)和机械通气组(15例),比较两组患者治疗后血气变化及症状缓解情况。结果:非机械通气组患者症状缓解平均时间为(90±20)min;机械通气组患者平均上机时间为(6±2)h。非机械通气组患者血气改善较机械通气组快(P<0.05)。结论:迅速有效地应用支气管扩张剂,对SFA具有较好疗效,而机械通气可则能延长血气改善和症状缓解所需时间。

Objective：To determine the effects of invasive mechanical ventilation on sudden-onset fatal asthma （SFA）. Methods：We did a retrospective analysis on the clinical profiles of 42 patients with SFA who were admitted to Shunfeng People＇s Hospital, Meizhou, between January 2001 and December 2011. All patients were allocated to non-mechanical ventilation group （ n = 27 ） and mechanical ventilation group （ n = 15 ） for further comparison on the changes in blood-gas indices and amelioration in the symptoms. Results：The time to resolved symptoms was （ 90 ± 20） minutes and （ 6 ± 2 ） hours in non-mechanical and mechanical ventilation group, respectively. Non-mechanical ventilation group yielded more rapid （ P 〈 0.05 ） amelioration in blood-gas indices than mechanical ventilation group. Conclusion ： Timely administration of bronchodilators is effective for the treatment of SFA, while mechanical ventilation may be associated with prolonged symptom amelioration and delayed improvement in blood-gas indices.