维生素D缺乏与婴幼儿哮喘发病的关系

Relationship between Vitamin D Deficiency and Asthma in Infants

目的:研究维生素D(VitD)缺乏与婴幼儿哮喘的关系。方法:选择支气管哮喘患儿120例,随机分为VitD治疗组和常规治疗组,同期体检健康儿童60例作为对照组;ELISA法检测血清25-(OH)D3水平,荧光酶联免疫法测定血清嗜酸性粒细胞阳离子蛋白(ECP),记录患儿1年内哮喘发作次数及喘息持续的时间。结果:(1)哮喘患儿血清25-(OH)D3水平较对照组低,血清ECP水平较对照组高,两组比较差异有统计学意义(P<0.05);(2)VitD治疗后患儿血清25-(OH)D3增高,血清ECP水平降低,治疗前后差异有统计学意义(P<0.05);(3)VitD治疗组1年内哮喘发病次数较常规治疗组少,发作时喘息持续的时间较常规治疗组短,差异有统计学意义(P<0.05)。结论:在支气管哮喘的治疗过程中,补充VitD可减少哮喘发作,缩短喘息持续时间。

Objective： To investigate the relationship between vitamin D deficiency and asthma in in- fants. Methods： One hundred and twenty children with bronchial asthma were randomly divided into VitD treated group and conventional treated group. Sixty healthy children who accepted physical exam- ination at the same iime served as controls. The serum levels of VitD and ECP were measured with ELISA. The frequency of asthma attack per year and the duration of asthma attack were recorded. Re- sult ： 1. The serum 25 - （OH） D3 level of the children with asthma was significantly lower than that of healthy controls, while ECP level was signifantly higher than that of healthy controls （ P 〈 0.05 ）. 2. There were significant differences in the levels of 25 - （OH） D3 and ECP in the VitD treated group be- fore and after VitD treatment. After VitD treatment, 25 - （OH） D3 level increased, while ECP level decreased （ P 〈 0.05 ）. 3. The frequency of asthma attack per year in VitD treated group was less than that of conventional treated group, and the duration of asthma attack was shorter than that of conven- tional treated group （ P 〈 0.05 ）. Conclusions： The pathogenesis of asthma is correlated with vitamin D deficiency. Supplying VitD can decrease the frequency of asthma attack and shorten the duration of asthma attack.