期刊文献+

阿奇霉素辅助治疗小儿喘息性支气管炎84例 被引量:9

下载PDF
导出
摘要 目的:观察阿奇霉素治疗小儿喘息性支气管炎的临床疗效。方法:84例小儿喘息性支气管炎患儿按照随机数表方法分为对照组和观察组,各42例;两组均采用常规治疗,观察组加用阿奇霉素10 mg/(kg.d)匀速静滴,1次/d,疗程5d,对比两组疗效和喘息症状消失时间。结果:观察组总有效率92.8%,对照组78.5%,两组比较差异有统计学意义(P<0.05);观察组咳嗽喘息及肺部哮鸣音消失时间早于对照组,住院时间短于对照组。结论:阿奇霉素辅助治疗小儿喘息性支气管炎疗效显著,安全性好。
出处 《贵阳医学院学报》 CAS 2012年第5期553-554,共2页 Journal of Guiyang Medical College
  • 相关文献

参考文献6

二级参考文献38

  • 1中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(草案)[J].中华结核和呼吸杂志,2005,28(11):738-744. 被引量:1455
  • 2Takizawa H, Desaki M, Ohtoshi T, et al. Erythromycin supperlesses interleukin-6 expression by human bronchial epithelial cells:a potential mechanism of its anti-inflammatory action[J]. Biochem Biophys Res Commun, 1995,210( 3 ) : 781 - 786.
  • 3Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of communityacquired respiratory tract infections and chronic inflammatory pulmonary conditions? [J]. J Antimicrob Chemother, 2005, 55(1):10- 21.
  • 4Hatipoglu U, Rubinstein I. Low-dose, long-term macrolide therapy in asthma: an overview[J].Clin Mol Allergy, 2004, 2(1) :4.
  • 5Wales D, Woodhead M. The anti-inflammatory effects of maerolides[J]. Thorax, 1999,54(2) : S58 - S62.
  • 6Sharma S, Jaffe A, Dixon G. Immunomodulatory Effects of MacrolideAntibiotics in Respiratory Disease: Therapeutic Implications for Asthma and Cystic Fibrosis[J]. Paediatr Drugs,2007 9(2) :107 - 118.
  • 7Rubin BK, Henke MO. Immunomodulatory activity and effectiveness of macrolides in chronic airway disease[J]. Chest,2004,125(2) :70S- 78S.
  • 8Kostadima E, Tsiodras S, Alexopoulos El, et al. Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma[J]. Eur Respir J ,2004,23(5) :714 - 717.
  • 9Johnston SL, Blasi F, Black PN, et al. The effect of telithromycin in acute exacerbations of asthma[J]. N Engl J Med,2006,354(15):1 589-1 600.
  • 10Simpson JL, Powell H, Boyle MJ, et al. Clarithromycin targets neutrophilic airway inflanlmation in refractory asthma[J].Am J Respir Crit Care Med,2008,177(2) : 148 - 155.

共引文献72

同被引文献52

引证文献9

二级引证文献48

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部