842株大肠埃希菌耐药性分析及分布

Analysis of drug resistance and distribution in 842 strains of Escherichia coli

目的了解我院院内大肠埃希菌(ECO)的耐药情况及其标本来源,为临床治疗及控制院内感染提供依据。方法对2011年1月～2011年12月临床分离的842株大肠埃希菌的耐药率及标本来源进行回顾性分析。结果收集的842株大肠埃希菌中,对亚胺培南、美罗培南、厄他培南、哌拉西林/他唑巴坦、阿米卡星、头孢西丁、阿莫西林/棒酸、头孢吡肟、头孢他啶、氨曲南、庆大霉素、妥布霉素、左氧氟沙星、环丙沙星、头孢噻肟、复方新诺明、头孢唑啉和氨苄西林的耐药率分别为0.24%、0.24%、0.24%、9.6%、17%、23%、33%、40%、43.3%、48%、54.2%、54.3%、56%、59%、60%、65%、76%、84.7%。842株大肠埃希菌主要从尿液(31.8%)和痰液(28.6%)中检出。结论大肠埃希菌为泌尿道感染和呼吸道的常见病原菌,临床上应根据耐药特点合理选用抗菌药物。

Objective： To investigate drug resistance and specimen source of Escherichia coli in hospital,thus guiding clinical treatment and controlling nosocomial infection.Methods： 842 strains of Escherichia coli were collected from Taian Central Hospital from January to November in 2011,whose drug resistance rates and specimen source were analyzed retrospectively.Results： Resistance rates of the 842 strains of Escherichia coli to Imipenem,meropenem,Ertapenem,piperacillin/tazobactam,amikacin,Cefoxitin,Amoxicillin/ Clavulanic,cefepime,ceftazidime,aztreonam,cidomycin,tobramycin,levofloxacin,ciprofloxacin,Cefotaxime,SMZ-TMP,Cefazolin and Ampicillin were 0.24%,0.24%,0.24%,9.6%,17%,23%,33%,40%,43.3%,48%,54.2%,54.3%,56%,59%,60%,65%,76% and 84.7% respectively.842 strains of Escherichia coli were mainly detected from urine（31.8%） and sputum（28.6%）.Conclusion： Escherichia coli are common pathogen which can cause infection in respiratory tract and urinary tract.Antibiotics should be chosen according to drug sensitivity test in the clinical practice.