他达拉非用于前列腺术后阴茎康复的研究进展

Tadalafil rehabilitation therapy for erectile dysfunction following prostatectomy

前列腺癌根治性切除术(RP)是治疗绝大多数临床局限性前列腺癌的标准术式,保留神经的NSRRP术式的广泛采用使得RP的疗效得到了显著的提升,但是对RP术后勃起功能的保护仍是泌尿外科的难题。RP术后及早开始阴茎康复可显著改善RP术后勃起功能障碍(ED)对患者的术后生活质量。作为唯一的长效选择性磷酸二酯酶-5抑制剂(PDE5Is),他达拉非在RP术后阴茎康复中的显著疗效在临床试验和基础研究中均得到了证实。本文旨在回顾目前RP术后ED的相关进展,及他达拉非在RP术后阴茎康复中的有效性和安全性证据。

Radical prostatectomy（RP）is preferred for many patients with clinically localized prostate cancer.Despite the introduction of the nerve sparing technique and progressive modifications on RP,postoperative preservation of penile erectile function remains a challenge to urologists.Earlier initiation of penile rehabilitation can significantly improve the patient＇s quality of life affected by erectile dysfunction（ED） following RP.Tadalafil,a long-acting PDE5 inhibitor with a unique clinical profile,has proved effective in penile rehabilitation in the treatment of RP-associated ED in both clinical trails and animal models.This article reviews current strategies for the management of ED after RP and evaluates the efficacy and safety of tadalafil in post-RP penile rehabilitation.