替米沙坦对慢性间断性缺氧小鼠血压的影响

Effect of Telmisartan on Blood Pressure of Mice under Intermittent Hypoxia Condition

目的通过探索睡眠呼吸暂停综合征（sleep apnea syndrome，SAS）引起的慢性间断性缺氧（chroni cintermittent hypoxia，CIH）对肾素．血管紧张素系统（reninangiotensinsystem，RAS）影响及血管紧张素受体阻滞剂（AngiotensinReceptorsBlocker，ARB）的保护作用。方法将32只清洁级雄性C57BL／6J小鼠随机分为CIH组、ARB替米沙坦干预组、空气模拟对照组和空白对照组，进行12周的模型试验。检测实验小鼠血压及鼠尾血流。结果（1）小鼠收缩压：CIH组小鼠收缩压高于ARB干预组、空气模拟对照组、空白对照组。ARB干预组收缩压则低于其余三组。（2）小鼠舒张压：ARB干预组小鼠舒张压低于其余三组。（3）鼠尾组织血流：CIH组小鼠组织血流量明显高于其他三组。结论慢性间断性缺氧可引起收缩压升高，ARB有良好的降压作用。慢性间断性缺氧可引起小鼠鼠尾组织血流量增多，ARB可逆转这种改变。

Objective To observe the effect of chronic intermittent hypoxia in sleep apnea syndrome patients on renin angiotensin system and the protection of angiotensin receptors blocker on cardiovascu- lar system, so as to explore the mechanism which sleep apnea syndrome act on cardiovascular system. Methods Thirty-two healthy male C57BL/6J mice were randomly divided into 4 groups： the CIH group, the telmisartan treatment group, the air control group, and the blank control group, with 8 mice in each group. The period of chronic intermittent hypoxia was lasted for 12 weeks. The blood pressure and blood flow of mouse tail were measured. Results （1） The level of systolic blood pressure in the CIH group was significantly higher than other groups and came down to the lowest after ARB treatment. （2） The level of diastolic blood pressure in ARB treatment group was significantly lower than other groups. （3） The tail blood flow of CIH group was significantly higher than those of the blank control group, the air control group, and the ARB treatment group. Conclusion The chronic intermittent hypoxia might induce high systolic blood pressure, and that ARB could decrease the hypertension caused by CIH. At the same time, CIH could increase the tail blood flow of mouse, and ARB could inverse this influence of CIH.