非酒精性脂肪性肝病与肝细胞癌关系的研究进展

Advances in nonalcoholic fatty liver disease and hepatocellular carcinoma research

非酒精性脂肪性肝病(NAFLD)作为一种与机体代谢紊乱相关的疾病,其发病率呈逐年上升趋势,随之引起肝脏代谢功能失调及相关病程进展,最终发展为脂肪性肝炎、隐源性肝硬化,甚至有可能发展为肝细胞癌(HCC)。本文就NAFLD相关HCC的发病机制、危险因素、诊断等作一综述。

The incidence of nonalcoholic fatty liver disease （NAFLD） is continuing to rise. Substantial research efforts have been allocated to uncover the etiologies and pathogenic mechanisms of this disease. These studies have revealed that NAFLD initially manifests as metabolic disturbance of liver function and can progress to adiposis hepatica, idiopathic cirrhosis, and hepatocellular carcinoma （HCC） ; however, the molecular processes, risk factors, and diagnostic indicators of NAFLD have yet to be definitively established. In this review, we summarize and discuss the latest research findings on these topics in order to provide a comprehensive overview of the current knowledge of NAFLD pro- gression to HCC and the aspects that remain to be elucidated.