摘要
研究了温度、相转移催化剂的种类和量、碱液浓度和配比、丙酮的配比和搅拌强度对氯代异戊烯与丙酮缩合生成甲基庚烯酮反应的影响。对特定的条件进行了反应产物的测定,得到了反应物浓度随时间变化的数据。建立了该反应系统的数学模型,用Rung-Kutta四阶求微分方程方法以及下降法求系统最佳化的方法得到各反应方程式中的反应速度常数。按这些速度常数模拟了该反应的整个过程,得到了满意的结果。设计计算了七节连续搅拌全混型反应塔,采用Powell最佳化的方法求得每一节的反应物浓度,计算结果和间歇实验数据的甲基庚烯酮浓度进行了比较,其结果也是比较接近的。
In this article, the effects of temperature, kinds and quantities of phase transfer catalysts, concentration and ratio of soda liquid, quantity of acetone and stirring intensity to the reaction of prenyl chloride and acetone, which produce 6-methyl-5-heptenon, were studied. From the measurement of reacted products under special condition, the data of reactant concentration, which is changed with time, was obtained. The math model for this reaction system was established, by using Rung-Kutts fourth degree method, the differential equation was solved. Then, with descending method, the optimum system was derived, and the reaction velocity constants in reaction equations were determined. Based on these constants, the whole procedure of the reaction was simulated and the result was satisfied. Finally, continuous mixing reaction tower with seven sections was designed, in which the reactant concentration form each section was calculated by using Powell method. The calculation result was compared with the experiment result, they are closed.
出处
《医药工程设计》
2012年第5期4-10,共7页
Pharmaceutical Engineering Design
