国产雷帕霉素长支架对患者心功能的中远期影响

The effects of the length of homemade sirolimus drug-eluting stents on the left ventricular function

目的评价置人国产雷帕霉素长支架对患者心功能的中远期影响。方法选择2010年2月至2011年2月，在长海医院心内科住院行冠脉造影及置人长、短支架的心绞痛患者共147例，根据置入支架长度分为≤20mm的短支架组（A组）、21-36mm的长支架组（B组）和〉36mm的串联长支架组（C组）。记录三组围术期急性并发症发生率及术后6个月的心脏彩超结果，比较三组间心功能的差异。结果①长支架组（B＋C组）术中急性并发症发生率为11．3％，远远高于短支架组（A组）的2．2％，但发生急性并发症对患者术后中远期的心功能影响差异无统计学意义。②置入A组短支架的患者，术后心功能平均改善为9．8±2.3；置入B组长支架的患者，术后心功能平均改善为8．6±1．3；置入C组长支架的患者，术后平均心功能改善为7．4±2．9，三组相比差异无统计学意义。③前降支（LAD）置入不同长度的支架，对术后心功能的改善均无统计学意义。结论置入国产雷帕霉素长支架的患者，术中急性并发症发生率高于置入短支架者，但对患者中远期的心功能无明显不良影响。

Objective To assess the impact of the long length of home-made sirolimus drug-eluting stents on the left ventricular function. Methods 147 patients who had successful underwent a single short or long stent or overlapping stents were evaluated. The patients were divided into three groups by the length of the stents （≤20, 21-36, 〉36 mm）. Before and 6 months after PCI, the pulsed-wave tissue Doppler imaging （pw-TDI） parameters were compared among the patients. Results The complication rate of the long stent group was 11.3%, which was higher than the short stent group（2.2%）. The average improvement of EF of the patients who underwent a short stent was 9.8±：2.3, and the single long stent group was 8.6：t：1.3, and the overlapping stent group was 7.4± 2.9. But six months after PCI, the myocardial function between the there groups has no significant differences. In whom underwent left anterior descending coronary artery （LAD） stent, there was no differences between them. Conclusion The acute complications in long home-made sirolimus drug-eluting stents are higher than the shorters, but there is no adverse effects during long-term follow-up.