苏南地区急性冠脉综合征患者危险因素相关性分析

Analysis of risk factors in patients with acute coronary syndrome in southern region of Jiangsu province

目的:探讨江苏省苏南地区急性冠脉综合征(ACS)患者危险因素的分布特点及其与预后的关系。方法:用中位数来计算苏南地区ACS患者危险因素的分布情况,并分析危险因素个数与预后的关系。结果:苏南地区ACS患者危险因素个数的中位数为5;在单个危险因素亚组中,年龄>5岁、高密度脂蛋白(HDL)<40 mg.dl-1(男性)或<50 mg.dl-1(女性)、高血压病、糖尿病、甘油三酯(TG)>150 mg.dl-1、前驱糖尿病的患者较无此类因素者危险因素个数的中位数之比为6∶5;而低密度脂蛋白(LDL)>70 mg.dl-1亚组中位数之比为5∶4;男性、早发冠心病家族史亚组中位数之比分别为6∶4、7∶5;吸烟、肥胖、CRP>2 mg.L-1亚组中位数之比为5∶5。所有患者危险因素个数从2～8,随着危险因素个数的增加,患者中远期主要不良心血管事件的发生率从19.3%增加到38.6%。结论:在本次调查的苏南地区人群中,男性、早发冠心病家族史将导致该患者总体危险因素个数增多,而年龄>65岁、HDL<40 mg.dl-1(男性)或<50 mg.dl-1(女性)、LDL>70 mg.dl-1、高血压病、糖尿病、TG>150 mg.dl-1、前驱糖尿病亦是危险因素增加的重要因素;同时随着危险因素个数的增加,患者发生心脑血管意外的风险相应增加。

Objective： To explore the characteristics of risk factors and prognosis of acute coronary syndrome（ACS） patients in southern region of Jiangsu province.Methods： Median was used to access the distribution of risk factors in patients with acute coronary syndrome in southern region of Jiangsu province and to analyze the relationship between the number of risk factors and prognosis.Results： The median of the number of risk factors was 5 in patients with ACS in the Southern region.In invariant risk factor sub-group,the median ratio between the group of age65 years,HDL40 mg·dl^-1（male） or 50 mg·dl^-1（female）,hypertension,diabetes,triglycerides150 mg·dl^-1,pre-diabetic and the group having no relative risk factors was 6∶5;the median ratio of the sub-group of LDL70 mg·dl^-1 is 5∶4;the median ratios of the sub-group of male and family history of premature coronary heart disease was respectively 6∶4,7∶5;the median ratio of the sub-group of smoking,obesity,CRP2 mg ·L^-1 was 5∶5.The number of risk factors was 2-8 for all patients,with the increase of risk factors numbers,the long-term incidence of MACE increased from 19.3% to 38.6%.Conclusion： In the southern region of Jiangsu province,risk factors of male and family history of premature coronary heart disease improve the total risk factors numbers,and age65 years,HDL40 mg·dl^-1（male） or 50 mg·dl^-1（women）,hypertension,diabetes,triglycerides150 mg·dl^-1,prediabetes,ect,also play important roles.The risk of cardiovascular and cerebrovascular accident increases along with the argument of the number of risk factors.