摘要
抗菌肽是一类广泛存在于生物体内的天然小分子多肽,它是机体免疫系统的天然组分,具有抗菌、抗炎及抗病毒等作用。许多抗菌肽具有抗肿瘤活性,而且在细胞选择性和耐药性方面也拥有独特的优势。本文综述抗菌肽的抗肿瘤机制及应用。
As a cluster of peptides, antimicrobial peptides are widely existed in many creatures in nature. It is evolutionarily conserved component of immune system with the fimction of antibacterial, anti-inflammatory and antivirus. Many kinds of antimicrobial peptides have antitumor effects with higher specificity against the resistance of tumor cells. This review summerizes progress of their antitumor mechanism and application.
出处
《世界临床药物》
CAS
2012年第10期620-626,共7页
World Clinical Drug
基金
上海市科委国际科技合作基金(11430707900)
教授部博士点基金(优先发展领域20110071130011)
国家自然科学基金委海外及港澳学者合作研究基金(81128015)
关键词
抗菌肽
抗肿瘤
作用机制
antimicrobial peptide
antitumor effect
action mechanism
