慢加急性重型乙型病毒性肝炎患者血清干扰素γ水平的检测及临床意义

Diagnostic Value and Clinical Significance of Serum Interferon-gamma in Patients with Acute-On-Chronic Hepatitid B Liver Failure

目的:探讨血清干扰素-γ(IFN-γ)在慢加急性重型乙型病毒性肝炎(acute-on-chroni hepatitis B lover failure,ACHBLF)发病中的作用,旨在为ACHBLF的诊治提供理论参考。方法:采用ELSIA法测定30例ACHBLF患者和30例CHB患者血清IFN-γ水平,采用全自动生化仪检测肝功能常规指标。结果:ACHBLF组IFN-γ水平显著高于CHB组,相比较有显著性差异(P<0.05);ACHBLF组TBIL、ALT水平显著高于CHB组,相比较有显著性差异(P<0.05);ACHBLF组PTA水平显著低于CHB组,相比较有显著性差异(P<0.05);ACHBLF患者的IFN-γ水平与TBIL呈显著正相关(r=0.818,P<0.01),与PTA呈显著负相关(r=-0.529,P<0.05),而与ALT无明显相关性(r=0.172,P>0.05)。结论:IFN-γ参与ACHBLF的发病,并且是ACHBLF病情严重程度的重要指标之一。

Objective： To explore the diagnostic value and clinical significance of serum interferon-gamma （IFN-γ） in patients with acute-on-chronic hepatitid B liver failure （ACHBLF）, and provide theoretical reference for the diagnosis and treatment of ACHBLF. Methods：The serum IFN-γ level of 30 cases of ACHBLF and 30 cases of CHB were detected by e ce lmmunoassay （ECLIA）, the conventional indicators of liver function were detected by automatic biochemical analyzer. Results：The IFN-γlevel of ACHBLF group was higher than the CHB group, and the difference was significant （P〈0.05）; The TBIL and ALT levels of ACHBLF group were higher than the CHB group, and the difference was significant （P 〈0.05）; The PTA level of ACHBLF group was lower than the CHB group, and the difference was significant （P〈0.05）. The IFN-γlevel had significant positive correlation with TBIL （r = 0.818, P〈0.01）, and negative correlation with PTA （r = -0.529, P〈0.05） but no correlation with ALT （r = 0.172, P〉0.05）. Conclusions： The IFN-γ involves in the pathogenesis of ACHBLF, and is an important indicator for evaluating the severity of ACHBLF.