摘要
目的:研究他汀类药物在改善阿尔茨海默病患者认知功能障碍的作用。方法:将阿尔茨海默病患者40例,随机分成治疗组(阿托伐他汀钙20 mg 1次/d口服)和对照组(茴拉西坦0.2 g 3次/天口服),连续用药90d,在30d、60d、90d分别对两组病人进行认知功能评分(简易精神量表)。结果:利用t检验的方法计算t值,30d比较,t=0.938(P>0.05,差异无统计学意义);60d比较,t=1.333(P>0.05,差异无统计学意义);90d比较t=2.356(P<0.05,差异具有统计学意义),提示90天后治疗组改善认知功能障碍优于对照组,且随着用药时间的延长,优势显现可能越为明显。结论:阿托伐他汀可能有助于阿尔茨海默病的治疗。
Objective： To investigate the effects of statins in improving cognitive dysfunction in Alzheimer＇s disease role. Methods： The Alzheimer＇s disease in 40 patients, randomly divided into treatment groups （atorvastatin 20mg 1 time / day orally） and control group （aniracetam 0.2g 3 times / day orally）, continuous medication 90d, in the 30d, 60d, 90d, respectively, cognitive function score of two groups of patients（Mini-Mental Scale ）. Results：Calculated using the t-test t-value, 30d comparison, t = 0.938 （P〉 0.05, the difference w- as not statistically significant）; 60d comparison, t=l.333（P〉0.05, the difference was not statistically significant）; 90d compare t = 2.356 （P 〈0.05, statistically significant difference）, suggesting that 90 days after the treatment group improved cognitive function than the control group, and with the treatment time, the advantage can be more obvious. Conclusion：Atorvastatin may contribute to the treatment of Alzh- eimer＇s disease.
出处
《现代生物医学进展》
CAS
2012年第28期5530-5532,共3页
Progress in Modern Biomedicine
