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骨髓增生异常综合征造血微环境若干问题研究进展 被引量：1

Research Advancs of Hematopoietic Microenvironment for Myelodysplastic Syndromes——Reviews
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摘要 骨髓增生异常综合征(MDS)是一组异质性克隆性疾病,其主要特征是病态造血、外周血细胞减少以及高风险向急性髓系白血病转化。越来越多的研究结果显示,骨髓造血微环境的异常在MDS发病和进展过程中发挥着重要的作用。本文就近年来有关MDS造血微环境中基质细胞、细胞因子、信号通路异常等方面的研究进展进行综述。 Myelodysplastic syndrome（MDS） is a group of heterogeneous clonal diseases characterized by ineffective hematopoiesis,peripheral blood cytopenias and high risk of transformation to acute myeloid leukemia.Recently more and more investigations indicate that the abnormality of bone marrow microenvironment is one of important reasons related to MDS.In this article the abnormality of stroma cells,cytokines and signaling pathways in hematopoietic micro-environment of MDS is reviewed.
作者 费成明 常春康
机构地区 上海交通大学附属第六人民医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2012年第5期1246-1250,共5页 Journal of Experimental Hematology
关键词 骨髓增生异常综合征 造血微环境 基质细胞 细胞因子 信号通路 myelodysplastic syndrome hematopoietic microenvironment stroma cell cytokine signaling pathway
分类号 R733.3 [医药卫生—肿瘤]
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参考文献23

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二级参考文献28

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中国实验血液学杂志
2012年 第5期

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