降眼压治疗对前部缺血性视神经病变PVEP的影响

The effect of lowering intraocular pressure on PVEP in anterior ischemic optic neuropathy

目的研究降眼压治疗对前部缺血性视神病变图形视诱发电位(PVEP)的影响。设计回顾性比较性病例系列。研究对象2008-2011年甘肃省第二人民医院住院的前部缺血性视神病变68例(68眼),非眼压干预30例(30眼)、眼压干预38例(38眼)。方法眼压干预组患者在发病时用药物降低眼压≥8 mm Hg或降低眼压≥30%。对两组患者患眼治疗前后的PVEP指标变化进行比较。主要指标PVEP P100潜伏期、P100振幅。结果眼压干预组P100潜伏期(93.82±1.97 ms)比非眼压干预组(对照组)(112.38±1.45 ms)短(t=46.36,P<0.001);眼压干预组P100振幅(3.64±0.23μv)比非眼压干预组(3.14±0.26μv)高(t=8.76,P<0.001)。结论降眼压治疗对前部缺血性视神病变PVEP有明显的利好作用。

Objective To study the influence of intraocular pressure（IOP）-lowering treatment on visual evoked potential （VEP） in eyes with anterior ischemic optic neuropathy（AION）. Design Retrospective comparative case series. Participants From 2008 to 2011, a total of 68 cases of AION in the Second People＇s Hospital of Gansu were enrolled. The participants were randomly divided into control group （non-lOP-intervention） with a total of 30 cases （30 eyes） and lowering IOP group （IOP intervention） with a total of 38 cases （38 eyes）. Methods The patients in IOP intervention group underwent an IOP lowering treatments to reduce IOP≥ 8 mm Hg or lower the IOP≥ 30%. All the eyes underwent pattern visual evoked potential （PVEP） test. The PVEP characteristies were analyzed both groups before and after treatment. Main Outcome Measures P100 latency, P100 amplitude of the PVEP. Results P100 latency in the intervention group （93.82＋1.97 ms） was significantly shorter than non-IOP intervention group （112.38±1.45 ms） （t=46.36, P〈0.001）; P100 amplitude in the intervention group（3.64±0.23 μv） was significantly higher than non-IOP intervention group （3.14±0.23 μv） （t= 8.76, P〈 0.001）. Conclusion Intraocular pressure-lowering treatment in AION eyes was benifitrial to PVEP.