血清S-CD105与VEGF联合监测复发转移性乳腺癌的意义

Clinical Significance of Serum S-CD105 and VEGF Levels of Patients with Postoperative Recurrent and Metastatic Breast Cancer

目的：探讨联合检测血清S-CD105和VEGF表达对乳腺癌术后复发、转移的临床意义。方法：用酶联免疫吸附实验（ELISA）分别检测50例复发转移性乳腺癌、20例原发性乳腺癌、20例乳腺良性疾病及15例健康女性血清S-CD105和VEGF的浓度；用微粒子化学发光法检测复发转移患者同期血清CEA、CA15-3的浓度。结果：复发转移性乳腺癌组血清S-CD105、VEGF浓度明显高于原发性乳腺癌组、乳腺良性疾病组及健康对照组（P〈0．05）。血清S—CD105与VEGF联合表达阳性率高于CEA与CA15-3联合表达率，差异有统计学意义（P〈0．05）。结论：复发转移性乳腺癌患者血清S-CD105与VEGF联合检测优于CEA与CA15-3联合检测，可能对乳腺癌患者术后复发转移的早期诊断有重要的临床价值。

Objective：To explore the levels and clinical significance of serum S-CDI05 and VEGF of patients with postoperative recurrent and metastatic breast cancer. Methods：Serum S-CD105 and VEGF of 50 postoperative patients with recurrent and metastatic breast cancer, 20 patients with primary breast cancer, 20 patients with breast benign disease, and 15 healthy controls were detected by ELISA. CEA, CA15-3 of the same patients were measured by microparticle chemilumin - escence immunoassay in corresponding period. Restilts：The serum S-CDI05 and VEGF levels of the patients with postoperative recurrent and metastatic breast cancer was much higher than primary breast cancer , breast benign disease and healthy controls （P 〈 0. 05 ）. The positive rate of the combining test of serum S-CD105 and VEGF of patients with postoperative recurrent and metastatic breast cancer was higher than that of CEA and CA15-3 （P 〈 0.05 ）. Conclusions ：The positive rate of combining test of serum S-CD105 and VEGF is higher than that of CEA and CA15-3. It is expected to be markers for the early diagnosis of recurrence and metastasis of breast cancer.