内镜与显微镜经鼻蝶窦垂体瘤术后生存质量研究

Comparison of Quality of Life after Endoscopic and Microscopic Transsphenoidal Surgery for Pituitary Adenoma

目的比较内镜与显微镜经蝶垂体瘤术后生存质量,为全面评估手术疗效提供依据。方法 2006年6月～2011年9月对105例垂体瘤分别施行内镜和显微镜经蝶手术,采用SF-36、HADS、MFI-20生存质量量表对41例内镜经蝶垂体瘤手术(内镜组)和64例显微镜经蝶垂体瘤手术(显微镜组)进行比较。结果 SF-36提示内镜组总体健康指数(71.6±21.9)分明显高于显微镜组(59.8±21.7)分(t=2.706,P=0.008);HADS提示2组焦虑指数无明显差异(t=0.518,P=0.615),抑郁指数亦无明显差异(t=0.128,P=0.899);MFI-20提示内镜组一般疲劳程度(10.2±4.3)分与显微镜组(11.3±5.3)分差异无显著性(t=-1.114,P=0.268)。结论内镜经蝶垂体瘤手术比显微镜经蝶垂体瘤手术使患者获得更满意的生存质量。

Objective To compare the quality of life （QOL） of the patients who underwent endoscopic or microscopic transsphenoidal surgery for pituitary adenoma, so that to form the basis for a comprehensive assessment of surgical treatments. Methods Totally 105 patients with pituitary adenoma, who underwent endoscopic or microscopic transsphenoidal surgery in our hospital since June 2006 to September 2011, were enrolled into this study. The validated health questionnaire SF-36, HADS, and MFI-20 were used to evaluate the QOL of the endoscope and microscope groups （n = 41 and 64, respectively）. Results SF-36 indicated that the general health index of the endoscope group （71,6 4-21,9） was significantly higher than that in the microscope group （59.8 4- 21.7; t = 2. 706, P = 0. 008）; while HADS suggested that no significant difference existed in the anxiety index and depression index between the two groups （ t = O. 518, P = 0. 615 ; and t = 0. 128, P = O. 899, respectlvely） ; and M FI-20 showed no significant difference in the general fatigue index （ 10.2 ± 4.3 vs. 11.3 ±5.3, t = - 1. 114, P = 0. 268）. Conclusion Endoscopic transsphenoidal surgery achieves higher QOL than microscopy for patients with pituitary adenoma.