磷脂酶C-γ1在肿瘤中的表达及其意义

Expression and its significance of phospholipase C-γ1 in tumors

肿瘤转移是癌症患者死亡的主要原因,而肿瘤转移与肿瘤细胞的增殖和侵袭密切相关。因磷脂酶C-γ1过表达增强肿瘤细胞的增殖和侵袭能力,故其可能成为肿瘤靶向治疗的潜在靶点。本文就磷脂酶C-γ1在细胞活动性中的作用,促进肿瘤的发展和扩散,在肿瘤发展转移中的机制等研究进展作一综述。

Metastasis is the main cause of death in the patients with cancers, which is associated closely with cellular proliferation and invasion. The overexpression of phospholipase C-γ1 can increase the ability of cancerous cells to invade and metastasize, so it maybe a therapeutic potential to counteract the metastatic dissemination. This paper reviewed the literatures about the significance of phospholipase C-γ1 in the motility of cells, increasing the ability of cancerous cells to invade and metastasize, and the mechanisms of tumor migration and invasion.