奥曲肽在肠梗阻治疗中的应用价值

The clinical value of octreotide in the treatment of intestine obstruction

目的探讨奥曲肽在肠梗阻治疗中的应用价值。方法将113例肠梗阻病人随机分为两组，对照组（53例）常规治疗，包括胃肠减压、灌肠、补液及抗感染治疗等；观察组（60例）在常规治疗的基础上加用奥曲肽，10d后比较两组病人临床症状及体征改善情况。结果腹痛缓解时间、腹胀缓解时间及肛门排气时间，观察组分别为（3．2±1．6）d、（2．8±1．5）d、（2．3±1．4）d，明显少于对照组的（5.2±1．8）d、（4．5±1．7）d、（4．6±1．9）d，差异均有统计学意义（P〈0．05）；住院时间观察组与对照组比较，差异有统计学意义（P〈O．05）。结论奥曲肽是治疗肠梗阻有效、经济、安全的药物。

Objective To explore the clinical value of octreotide in the treatment of intestine ob- struction. Methods All of the 113 patients were divided into two groups randomly： routine treatment group （53 cases）, including gastrointestinal decompression, intravenous infusion, antibiotic and enema, and observation group which is routine treatment group combined with octreotide （60 cases）. Com- pared the improvement of clinical symptoms and signs with the two groups after 10 days. Results The average relieve time of abdominal pain and distension and anal exhaust time in observation group is （3. 2 ± 1.6） d, （2. 8 ± 1.5） d, （2. 3 ± 1.4） d respectively, which is significantly less than routin treat- ment group, which is （5. 2 ± 1.8） d, （4. 5 ± 1.7） d, （4. 6 ± 1.9） d respectively. Conclusion Octreotide is effective and safe in the treatment of intestine obstruction.