丹红注射液治疗下尿路梗阻引起慢性肾功能不全23例

Danhong Injection for Treatment of Chronic Renal Insufficiency Caused by Lower Urinary Tract Obstruction in 23 Patients

目的:观察丹红注射液治疗下尿路梗阻引起慢性肾功能不全的临床疗效。方法:选择下尿路梗阻引起慢性肾功能不全(返流性肾病)的患者44例,所有患者均先行导尿或膀胱穿刺造瘘后解除尿路梗阻,再随机分为2组。治疗组23例患者尿液引流后加用丹红注射液治疗,对照组21例患者尿液引流后予观察治疗,比较2组疗效:包括血肾功能测定(尿素氮、肌酐)、肾脏彩色多普勒血流显像(CDFI)测定肾动脉阻力指数(RI)和搏动指数(PI)、放射性核素肾动态功能显像(ECT)检查肾小球滤过率(GFR)等。结果:2组患者治疗后上述指标均有改善,且治疗组疗效明显优于对照组。2组患者尿液经引流后血清尿素氮、肌酐、肾动脉阻力指数(RI)和搏动指数(PI)、肾小球滤过率(GFR)有改善,治疗前后对比差异有统计学意义(P<0.05)。但使用丹红注射液治疗组较单纯采用引流尿液的对照组患者,其血清肌酐的下降程度、肾动脉阻力指数(RI)的下降、搏动指数(PI)下降、肾小球滤过率(GFR)的增加差异有统计学意义(P<0.05),疗效更好。结论:丹红注射液对下尿路梗阻引起慢性肾功能不全(返流性肾病)的患者临床疗效明显,值得临床推广使用。

Objective：To observe efficacy of Danhong Injection for Treatment of chronic renal insufficiency caused by lower urinary tract obstruction. Methods：Forty - four patients with chronic renal insufficiency （chronic reflux nephropathy） underwent urinary catheteriza- tion or bladder pneumatic lithotripsy to relieve urinary tract obstruction before randomization. Then 23 patients took Danhong Injection, and were compared with other 21 patients in terms of kidney function assessment （ urea nitrogen,creatinine）, renal arterial resistive In- dex （RI） and pulsatility index （PI） assessed by CDFI, GFR assessed by ECT, etc. Results：Mter treatment both groups had significant improvement in urea nitrogen, creatinine, RI, PI, GFR （P 〈 0.05）. Compared with those of the control group, the treatment group had lower levels of plasma creatinine, RI, PI, and increased GFR （P 〈 0.05 ）. Conclusion ： Danhong Injection can treat chronic renal in- sufficiency （chronic reflux nephropathy） caused by lower urinary tract obstruction, and it is recommendable in clinical application.