RhoE在胶质瘤组织中的表达及意义

Expression and significance of RhoE in glioma tissue

目的探讨RhoE蛋白在胶质瘤恶性进展中的作用以及与临床预后的关系。方法应用免疫组化法检测2例正常脑组织和37例不同病理级别人脑胶质瘤瘤组织中RhoE蛋白表达情况,评估RhoE蛋白表达与胶质瘤的病理分级及临床预后的关系。结果 RhoE蛋白在正常脑组织和胶质瘤中的免疫染色评分分别为7.00±1.00和3.32±0.372。RhoE蛋白表达与胶质瘤恶性程度呈负相关,相关系数r=-0.733。RhoE蛋白免疫染色评分小于4的胶质瘤患者生存期较短(P<0.05)。结论 RhoE在胶质瘤的发生进展中呈负调控作用,RhoE的低表达与胶质瘤临床预后较差相关,其表达情况对判断胶质瘤患者的预后有一定的参考价值。

Objective To investigate the roles of RhoE in the malignant progression of glioma and evaluate the relationship between expression of RhoE and clinical prognosis. Methods Expression of RhoE protein was assessed by immunohistochemistry in 2 normal brain tissues and 37 glioma samples of different tumor grade and was statistically analyzed in combination with the follow- up survival data of patients. Results The IRS of RhoE in normal brain tissues and glioma samples was 7.00± 1.00 and 3.32 ± 0.372 respectively. Decreasing expression of RhoE is closely correlated with increasing tumor grade of glioma （ r = -0. 733 ）. The glioma patients with IRS less than 4 had significantly shorter overall survival （ P 〈 0.05 ）. Conclusions Reduced expression of RhoE may take part in the development of glioma. Low expression of RhoE may correlate with poor prognosis of glioma patients and expression of RhoE maybe helpful to evaluate prognosis of glioma patients.