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中药添加剂降低烟气悬凝物诱导16HBE细胞TNF-α、IL-8及气道黏液蛋白基因mRNA高表达的实验研究 被引量：2

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摘要 目的:研究中药添加剂降低烟气悬凝物诱导16HBE细胞TNF-α、IL-8及MUC5AC mRNA高表达的作用。方法:CCK-8法检测细胞活力,RT-PCR法检测TNF-α、IL-8及MUC5AC mRNA表达水平。结果:CSC染毒后细胞活力下降,TNF-α、IL-8及MUC5AC mRNA表达水平升高。中药添加剂组细胞活力高于普通烟组,mRNA表达水平有所下降。结论:中药添加剂具有抑制CSC诱导16HBE细胞活力下降及TNF-α、IL-8及MUC5AC mRNA高表达的作用。
作者 魏民巍 郑赛晶 孟庆乃 金永明 周昆 胡利民
机构地区 天津中医药大学中医药研究院天津市中药药理学重点实验室 上海烟草(集团)公司技术中心
出处 《长春中医药大学学报》 2012年第5期776-778,共3页 Journal of Changchun University of Chinese Medicine
关键词 中药添加剂 16HBE细胞 烟气悬凝物 气道黏液蛋白基因 mRNA表达
分类号 R285.5 [医药卫生—中药学]
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参考文献13

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长春中医药大学学报
2012年 第5期

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