摘要
以3-羟基-4-甲氧基苯甲醛为原料,在甲酸、甲酸钠、盐酸羟胺作用下,将醛基转化为氰基,在含有碳酸钾的DMF中,所得化合物与N-(3-氯丙基)吗啉反应得目标化合物,总收率为87.5%。产物结构由1HNMR表征。本方法具有操作简单、易于纯化、收率高等特点,为工业化生产提供实验基础。
The titled compound was synthesized from 3-hydroxy-4-methoxybenzaldehyde.The formyl group was transformed to cyano group via the reaction with hydroxylammonium sulfate in the presence of sodium formate in formic acid,then the corresponding intermediate reacted with N-（3-chloropropyl）morpholine,the total yield was up to 87.5%.The products were characterized with 1H NMR.The synthetic route exhibits the advantages in purification and total yield of the final product compared with the previous ones.
出处
《化学通报》
CAS
CSCD
北大核心
2012年第10期945-947,共3页
Chemistry
