血清PCT和IL-6水平在脓毒症患儿中的诊断价值

Values of serum PCT and IL-6 levels for diagnosis of children with sepsis

目的:探讨降钙素原(PCT)和IL-6在脓毒症诊断中的价值。方法:应用LU-Mltest半自动定量法和酶联免疫吸附法分别测定30例未患脓毒症患儿和60例脓毒症患儿有效治疗前后血清PCT含量、IL-6含量及APACHEⅡ评分。同时比较两组患儿治疗后体温变化和WBC计数差异。结果:治疗前两组患儿PCT、IL-6和APACHE-Ⅱ评分结果比较显示,脓毒症组PCT、IL-6水平明显高于对照组(P<0.05),而APACHE-Ⅱ评分无统计学差异(P>0.05)。治疗后,脓毒症组患儿体温变化显著大于对照组(P<0.05),WBC计数无统计学差异(P>0.05)。随着治疗时间的进展,PCT、IL-6水平逐渐降低(P<0.05)。结论:PCT和IL-6含量检测对患儿脓毒症的早期诊断和疗效判定具有一定价值。

Objective：To explore the values of serum procalcitonin（PCT） and interleukin-6（IL-6） levels for diagnosis of children with sepsis. Methods：LU-Mltest semi-automatic quantitative method and ELISA were used to detect the contents of serum PCT and IL-6,and APACHE Ⅱ scores in 30 children without sepsis（control group） and 60 children with sepsis（sepsis group） before and after effective treatment.Meanwhile,the changes of temperature and WBC count after treatment in the two groups were compared. Results：Before treatment,the levels of serum PCT and IL-6 in sepsis group were statistically significantly higher than those in control group（P〈0.05）,but there was no statistically significant difference in APACHE Ⅱ score between the two groups（P〈0.05）.After treatment,the change of temperature in sepsis group was statistically significantly larger than that in control group（P〈0.05）,but there was no statistically significant difference in WBC count between the two groups（P〈0.05）.The levels of PCT and IL-6 decreased gradually with the progress of treatment（P〈0.05）. Conclusion：Detecting the contents of PCT and IL-6 has a certain value for early diagnosis and evaluation of therapeutic effect in children with sepsis.