肥胖与更年期女性乳腺癌的危险因素分析

Analysis on the relationship between obesity and risk factors of breast cancer in menopausal women

目的:探讨肥胖与更年期女性乳腺癌的发病危险因素。方法:对58例女性乳腺癌患者临床资料进行分析,并与同期进行常规体检的106例健康女性做对比性分析。结果:非条件多元Logistic回归分析中,体重指数及甘油三酯组P值存在显著差异,体重增加1个等级乳腺癌危险性增加OR4.78～10.63;甘油三酯增加1个等级乳腺癌危险性增加OR5.66～8.67,随着体重指数及甘油三酯增加,随之乳腺癌危险性也呈增加趋势。结论:更年期女性乳腺癌的发病与肥胖、高甘油三酯存在正相关关系,控制高热量饮食及体重的增加,加强体育锻炼对预防乳腺癌具有重要作用。

Objective：To explore obesity and risk factors of breast cancer in menopausal women. Methods：The clinical data of 58 female patients with breast cancer from the hospital were analyzed,then the results were compared with those of 106 healthy women who received physical examination during the same period in the hospital,a control study was performed. Results：Non-conditional multivariate logistic regression analysis showed that there was statistically significant difference in body mass index（BMI） and triglyceride level between the two groups;when the grade of BMI increased by one,the OR value of risk factors of breast cancer increased by 4.78-10.63;when the grade of triglyceride level increased by one,the OR value of risk factors of breast cancer increased by 5.66-8.67;the risk of breast cancer showed an increasing trend with the increases of BMI and glyceride level. Conclusion：The onset of breast cancer in menopausal women is positively correlated with obesity and high glyceride level;controlling the intake of high calorie diet and the increase of body weight,enhancing physical exercises play important roles in preventing breast cancer.