摘要
多表位疫苗是指同时携带多个与目标抗原相关的表位以及辅助性表位的疫苗。因其在细胞免疫方面的独特优势,已成为肿瘤疫苗研究领域的热点之一。随着分子生物学及免疫学等学科的飞速发展,使得多表位疫苗的临床应用也有了很大的进展。本文主要对多表位疫苗的选择、设计及临床应用等方面作一综述。
Multi-epitope vaccine, which carries several adjuvant epitopes and more than one epitope related to targeted antigens, has become one of the hotspots in the field of cancer vaccine development because of its unique advantages in cellular immunity. With the rapid development of molecular biology and immunology, the clinical application of muhi-epitope vaccine has made great progress. In this paper, the choice, design and clinical application of multi-epitope vaccine were reviewed.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2012年第10期588-593,共6页
Chinese Journal of New Drugs and Clinical Remedies
关键词
多表位疫苗
癌症疫苗
免疫疗法
主动
分子生物学
multi-epitope vaccine
cancer vaccines
immunotherapy, active
molecular biology