络石内生真菌Myrothecium roridum(IFB-E009)次生代谢产物的研究

Study on Secondary Metabolite of Trachelospermum jasminoides Endophyte Myrothecium roridum(IFB-E009)

该试验从络石(Trachelospermum jasminoides)内生的露湿漆斑菌属真菌Myrothecium roridum(IFB-E009)液体发酵产物中分离并鉴定了8个化合物,其中化合物1～4为单端孢霉烯类化合物,5～6为酰胺类化合物,7为环二肽化合物,8为尿嘧啶。活性测试表明,化合物1、4有细胞毒活性,对SW1116(人结肠癌细胞株)具有抑制作用,IC50分别为25.68和38.93μmol/L,而对照药阿霉素的IC50为5.31μmol/L。该研究可为开发利用药用植物内生菌提供理论和实践依据。

Eight compounds were isolated and identified from liquid fermentation products of Myrothecium roridum（IFB-E009） in Trachelospermum jasminoides,1-4 were trichothecenes compounds,5-6 were amides compounds,7 was cyclic peptide,and 8 was uracil.As indicated by activity test,compound 1,4 showed activities to the human colon cancer cells SW1116.IC50 were 25.68 and 38.93 μmol/L,while the IC50 of adriamycin was 5.31 μmol/L.The study would provide theory and practice basis for the development and utilization of endophytes in pharmaceutical plants.