支气管哮喘合并变应性鼻炎上下气道共治的临床观察

Clinical observation of upper and lower airway concomitant therapy in patients with allergic rhinitis and bronchial asthma

目的探讨上、下气道共治方法治疗支气管哮喘合并变应性鼻炎的临床效果及其安全性。方法 90例支气管哮喘合并常年变应性鼻炎的患者,按照数字随机表法分为A组(n=30)、B组(n=30)和C组(n=30),A组患者应用沙美特罗替卡松粉吸入剂,B组患者应用布地奈德鼻喷雾剂,C组应用沙美特罗替卡松粉联合布地奈德喷雾剂;对比临床治疗效果。结果治疗12周后,C组的哮喘症状记分、第1秒用力呼气容积、外周嗜酸粒细胞百分比(EOS%)、痰EOS%改善明显优于A组和B组,差异均有统计学意义(P<0.05);三组均未出现严重不良反应。结论沙美特罗替卡松粉吸入剂联合布地奈德喷雾剂治疗支气管哮喘合并变应性鼻炎疗效显著、安全,能够全面地控制上、下气道炎症,具有临床推广价值。

Objective To explore the clinical efficacy and safety of upper and lower airway concomitant therapy in patients with allergic rhinitis and bronchial asthma.Methods 90 patients with allergic rhinitis and bronchial asthma were randomly divided into A group（n=30）,B group（n=30） and C group（n=30）.A group took salmeterol-fluticasone propionate dry powder for inhalation.B group took budesonide nasal spraying agent.C group took salmeterol-fluticasone propionate dry powder and budesonide nasal spraying agent.The clinical effects were measured then.Results ACT scores,FEV1%,EOS% of peripheral blood,EOS% of sputum in C group were much better than that of the A group and the B group.Conclusion Salmeterol-fluticasone propionate dry powder combine with budesonide nasal spraying agent was effective and safety for patients with allergic rhinitis and bronchial asthma.