单纯生长激素缺乏青少年垂体MRI表现与生长激素激发峰值的相关性研究

MRI of Pituitary Gland Morphology in Idiopathic Growth Hormone Deficiency in Stage of Adolescent and Its Correlation with Provocation Peaked of Growth Hormone

目的探讨单纯生长激素缺乏症(isolated growth hormone deficiency,IGHD)青少年的腺垂体各径线值与临床生长激素(growth hormone,GH)激发峰值的关系,为临床诊断提供影像学依据。方法搜集52例临床确诊为IGHD的青少年(7.2～18.3岁)行垂体MRI检查,测量腺垂体各径线并与正常对照组比较;分析其腺垂体各径线及其与GH激发峰值的关系。结果男性患者中,10～<15岁和15～<18.3岁的冠状高径、矢状高径均比正常对照组减小(P<0.05);女性患者中,10～<15岁的冠状高径、矢状高径、矢状前后径均比正常对照组减小(P<0.05)。IGHD患者的腺垂体各径线值在不同性别组和不同年龄组间比较,差异无统计学意义。IGHD患者腺垂体的冠状高径与GH激发峰值呈正相关(r=0.38,P<0.01;r=0.32,P<0.05)。结论 IGHD患者腺垂体各径线值不随性别和年龄而改变,且其腺垂体冠状高径与GH激发峰值呈正相关。

Objective To study diameter of adenohypophysis with isolated growth hormone deficiency（IGHD） in stage of adolescent and its correelation with provocation peaked of growth hormone（GH）.Methods 52 cases of MRI data of adenohypophysis in IGHD adolescents range from7.2 year to 18.3 year were used,which were divided into 6-〈10 years old,10-〈15 years old,15.0-18.9 year group in adolescents.Using 1.5 T MR scanner,the appearances of adenohypophysis in 52 IGHD adolescents were analyzed on T1WI in sagittal and coronal plane,and to compare with normal control.Relation of the diamete of adenohypophysis in sagittal and coronal plane with GH provocation peak was analyzed.ResultsThe coronal and sagittal height diameter of adenohypophysis in 10-〈15 years old year group and 15-〈18.3 years old year group for male was grow down compare with normal control（P〈0.05）.The coronal and sagittal height diameter and sagittal anteroposterior diameterof adenohypophysis in 10~〈15 years old year group for female was grow down compare with normal control（P〈0.05）.The difference of diameter value of adenohypophysis with IGHD in different gender group and different age group was not statistically significant.The coronal and sagittal height diameter of adenohypophysis with IGHD was positive correlation with provocation peaked of GH（r=0.38,P〈0.01;r=0.32,P〈0.05）.Conclusion The diameters of adenohypophysis with IGHD do not change following the gender and age.The height diameter of adenohypophysis with IGHD is positive correlation with provocation peaked of GH.