脂联素受体表达与大肠癌发生发展的相关性研究

The correlation research of adiponectin receptors expression with the occurrence and progression of colorectal carcinoma

目的研究脂联素（adiponectin，ADP）受体（AdipoR1、AdipoR2）表达与大肠癌发生发展的相关性。方法应用免疫组织化学SP法检测55例大肠癌组织中ADP受体的表达，并结合大肠癌临床病理因素进行分析。结果AdipoR1在大肠癌组织中的阳性表达率为85．45％（47／55）,AdipoR2在大肠癌组织中的阳性表达率为78．18％（43／55）。AdipoR1和AdipoR2的表达与患者的年龄和性别无关（P均〉0．05），与大肠癌浸润深度、淋巴结转移以及肿瘤分化程度均有关（P均〈0．05）。AdipoR1阳性表达与癌组织浸润深度呈负相关关系（r=-0．423，P〈0．01）。结论ADP受体的表达水平与大肠癌的发生发展相关。

Objective To study the correlation of the expression of adiponectin（ADP） receptors（ Adi- poR1. AdipoR2） with the coccurrence and progression of colorectal carcinoma. Methods The expression of ADP receptors in the colorecta1 carcinoma tissue of 55 cases patients were detected by immunohistochemical SP method, and the results were analyzed combined with pathology factors. Results The positive rates of Adi- poR1 and AdipoR2 in cololectal carcinoma tissue were 85.45% （47/55） and 78,18% （43/55） respectively. There were no relationship was found between adiponectin receptors expression and the patient＇s age and gen- der（Pall〉 0.05 ）. There were relationship between the expression of adiponectin receptors with the depth of tu- mor invamon.lymph node metastasis and the degree of differentiation （Pall〈 0.05）. The expression of AdipoRl had negative correlation with the depth of tumor invasion （r= -0.423, P〈 0.01 ）. Conclusion The expression of adiponectin receptors have correlation with the coccurrence and progression of colorectal carcinoma.