刚地弓形虫免疫逃避相关分子的研究进展

Immune Evasion Molecules of Toxoplasma gondii

刚地弓形虫可依赖有效的免疫逃避机制在宿主体内长期生存,造成慢性感染。纳虫泡膜、棒状体和细胞质等所含抗原物质多而复杂,在弓形虫逃避宿主的免疫应答中起重要作用。它们通过抑制过度炎症反应和一氧化氮产生,影响细胞因子基因表达,耗竭特异性免疫反应物质,以及下调免疫细胞功能等方式有效地逃避宿主免疫反应攻击。本文就弓形虫免疫逃避相关分子的最新研究进展作一综述。

Toxoplasma gondii can live in the host for a long time relying on effective immune escape mechanisms and cause a chronic infection. Different antigenic molecules in the parasitophorous vacuole membrane, rhoptry and cytoplasm play an important role in evading the host＇s immune response. They can effectively help avoid the host immune response by inhibiting excessive inflammatory response and production of nitric oxide, affecting gene expression of some cytokines, depleting the specific immune substances, reducing the function of immune ceils and so on. This paper summarizes the latest research advances in molecules related to the immune evasion of T. gondii.