sALP、sNTX与下颌骨骨密度改变的相关性分析

Association Analysis between sALP,sNTX and the Change of Mandibular Bone Mineral Density

目的:探讨下颌牙列缺损人群血清碱性磷酸酶(sALP)和I型胶原氨基末端肽(sNTX)随年龄变化及其下颌骨PIM指数之间的关系。方法:选用下颌牙列缺损健康患者60例,年龄20～79岁,分成6个年龄段,10岁为一年龄段,其中男性40名、女性20名。全景曲面断层采用PMI指数测量受试者,同时抽取血清测试骨生化指标sALP和sNTX。根据测试数据进行分析。结果:PMI和sALP、sNTX的性别间比较:4个指标均未见具有统计学意义的性别差别。下颌骨密度指标和骨生化指标与年龄关系:下颌骨密度指标(sPMI、iPMI)与年龄呈高度负相关(r值为-0.845,-0.917,P<0.001),骨生化指标(sALP、sNTX)与年龄呈正相关(r值为0.946,0.423,P<0.001)。sALP和sNTX在20～39岁年龄段较低,自40～49岁年龄段开始明显升高(P<0.001),sPMI和iPMI在50～59岁年龄段较30～39岁之前年龄段显著下降(P<0.001)。结论:年龄是下颌骨密度指数和骨生化指标变化的重要因素;sALP和sNTX反映下颌骨高骨转换状态,是下颌骨量丢失的重要因素之一;sPMI和iPMI是反映下颌骨密度改变的敏感指标。

Objective： To investigate the relationship between serum alkaline phosphatase（sALP）,type I collagen amino-terminal peptide（sNTX）,mandible PIM and age in people with mandibular defects.Methods： We chose 60 cases of healthy patients with mandubular defects,including 40 males and 20 females,who aged from 20 to 79,then divided all cases into six age groups with ten years as age range.We used PMI to evaluate all subjects by panorama panoramic.Serous sALP and sNTX were also measured to evaluate all subjects.Results： All the indicators show no statistically significance by gender.The mandibular bone mineral density index（sPMI and iPMI） showed a highly negative correlation with age（r=-0.845,-0.917,P0.001）,while bone biochemical markers（sALP,sNTX） were positively correlated with age（r value of 0.946,0.423,P0.001）.sALP and sNTX were lower in group of 20 to 39,and began to increase significantly in group of 40 to 49（P0.001）;While sPMI and iPMI decreased more significantly in group of 50 to 59 compared with group of 30 to 39（P0.001）.Conclusion： Age played an important role in evaluating the change of mandibular bone mineral density and bone biochemical markers.Mandible sALP and sNTX reflected the high bone turnover state,and was an important factor in evaluating the loss of mandible;sPMI and iPMI could reflect lower jaw bone density.