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酪氨酸激酶受体Tie-2在不同肿瘤中的表达及治疗展望 被引量：1

Expression and Treatment Prospect of Tyrosine Kinase Receptor Tie-2 in Different Tumors
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摘要 Tie-2为内皮细胞特异性酪氨酸激酶受体。本文综述了Tie-2的功能、生理作用等。Tie-2在多种肿瘤中表达,在大肠癌中也有明显高表达。Tie-2作为一种新候选的肿瘤标志,将有助于肿瘤的诊断及预后检测,并为高表达Tie-2的肿瘤治疗提供新的靶点,为重组可溶性Tie-2成为肿瘤基因治疗提出了先决条件。 Tie-2 is the endothelial cell-specific tyrosine kinase receptor.The function and physiological role of Tie-2 are reviewed.It expresses in many tumors,and it has a high expression in colorectal cancer.As a new candidate tumor marker,Tie-2 will be helpful to the diagnosis and prognosis detection of the tumors.It provides a new target spot for the treatment of tumors with high Tie-2 expression.The recombinant soluble of Tie-2 provide a prerequisite for the cancer gene therapy.
作者 冯瑞 李云峰
机构地区 昆明医学院 云南省肿瘤医院大肠癌临床研究中心
出处 《现代诊断与治疗》 CAS 2012年第7期898-900,共3页 Modern Diagnosis and Treatment
关键词 Tie-2肿瘤表达 大肠癌 基因治疗 Tie-2 Tumor expression Colorectal cancer Gene therapy
分类号 R363 [医药卫生—病理学]
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参考文献16

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现代诊断与治疗
2012年 第7期

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