不同空腹血糖受损诊断标准下人群代谢特征比较

Comparison of metabolic characteristics in patients with different diagnostic criteria for impaired fasting glucose

目的:从预测代谢性疾病的角度探讨空腹血糖受损(IFG)诊断下限从6.1mmol/L下调至5.6mmol/L的合理性。方法:比较正常糖代谢组(NGT,FPG<5.6mmol/L)、空腹血糖受损组1(IFG1,5.6mmol/L≤FPG<6.1mmol/L)和空腹血糖受损组2(IFG2,6.1mmol/L≤FPG<7.0mmol/L)之间代谢指标及发生代谢性疾病风险的差异。结果:与NGT组相比,IFG两组人群的血压、血脂等指标均显著升高(P<0.05)。与IFG1组相比,IFG2组仅部分代谢指标显著升高(P<0.05)。Logistic回归分析显示,与NGT组相比,IFG1与IFG2组发生中心性肥胖、高血压、高甘油三酯血症、代谢综合征的风险均升高(P<0.05),而IFG两组间则无显著差异(P>0.05)。结论:从疾病早期防控的角度出发,将IFG诊断下限下调为5.6mmol/L是合理的,应加强对人群空腹血糖的筛查。

Objective To investigate whether the lower threshold of impaired fasting glucose（IFG） should be revised from 6.1 mmol/L to 5.6 mmol/L from the perspective of predicting metabolic diseases.Methods Differences of metabolic indicators and the risks of metabolic diseases were compared among three groups：the normal glucose tolerance（NGT） group with FPG 〈 5.6 mmol/L,the IFG1 group with 5.6 mmol/L ≤ FPG 〈 6.1 mmol/L,and the IFG2 group with 6.1 mmol/L ≤ FPG 〈 7.0 mmol/L.Results Compared with NGT,many metabolic indicators were elevated in the two IFG groups（P 〈 0.05）,and there was only few indicators elevated in the IFG2 group（P 〈 0.05） compared with IFG1.In logistic regression analysis with adjustment for age and gender,compared with NGT,IFG1 and IFG2 were both associated with higher risks of metabolic diseases,while there was no significant difference of risks for every metabolic disease between IFG1 and IFG2.Conclusions It is rational to revise the lower threshold of IFG from 6.1 mmol/L to 5.6 mmol/L from the perspective of early prevention and control of metabolic diseases.