小剂量氨茶碱对COPD稳定期患者血浆及诱导痰中IL-13水平的影响

Effects of low-dose aminophylline on the levels of IL-13 in plasma and induced sputum in patients with stable chronic obstructive pulmonary disease

目的:探讨小剂量氨茶碱对COPD稳定期患者慢性气道炎症的影响。方法:将40例COPD稳定期患者随机分为治疗组和对照组各20例,两组均给予常规家庭氧疗及肺功能锻炼,治疗组此基础上加用氨茶碱100mg每天3次口服,30d后比较两组患者血浆和诱导痰IL-13水平。此外还检测了10例健康个体血浆和诱导痰中IL-13水平。结果:在治疗组与对照组中,无论是血浆还是诱导痰中IL-13水平均高于健康个体,差异有统计学意义(P<0.05);同时治疗组患者血浆和诱导痰IL-13水平显著低于对照组,差异有统计学意义(P<0.05)。结论:COPD稳定期患者应用小剂量氨茶碱能通过降低IL-13而具有显著的抗炎症作用。

Objective To investigate the effects of low-dose aminophylline on chronic airway inflammation in patients with stable chronic obstructive pulmonary disease（COPD）.Methods 40 patients with stable COPD were randomly divided into 2 groups：aminophylline group（n = 20） and control group（n = 20）.All patients in both groups received routine home oxygen therapy and pulmonary functional exercise,and the patients in aminophylline group also received 100mg of aminophylline orally,three times a day.The levels of IL-13 in blood and induced sputum（IS） samples harvested from COPD patients and 10 cases of healthy controls before and 30 days after the treatment were determined by ELISA assay.Results The levels of IL-13 in plasma and IS were higher in both aminophylline group and control group than those in healthy controls,respectively（P 〈 0.01）.Meanwhile,the levels of IL-13 in both plasma and IS were lower in aminophylline group than those in control group（P 〈 0.01）.Conclusions Aminophylline could significantly exhibit the anti-inflammatory effect by decreasing the level of IL-13 in both plasma and IS in patients with stable COPD.