摘要
MicroRNA(MiRNA)是一类长约18～22个核苷酸的小分子非编码RNA,能调节转录后靶基因的表达,其在机体内的生长发育,细胞繁殖、代谢、凋亡等生理过程中发挥着重要作用。MiRNA具有癌基因或抑癌基因的双重作用,且具有组织特异性。MiRNA表达水平的变化与肿瘤形成密切相关。肺癌是严重危害人类健康的疾病,其发病率和病死率已占全球恶性肿瘤的首位。其恶劣预后多归因于早期诊断能力差和治疗效果欠佳。近年来,在肺癌诊断中具有高度敏感性和特异性的MiRNA备受关注。作为血清标志物,MiRNA将为肺癌早期诊断提供了新的重要的途径。
MicroRNA（MiRNA） are small non-coding RNA of 18-22 nucleotides which participate in regulating gene expression in posttranscriptional level.To mankind,MiRNA play important roles in the physiological precesses of cell growth,cell proliferation,metabolism,apoptosis and so on.Different MiRNA may act to as oncogenes or antioncogenes,and all of them have tissue specificity.The changes of MiRNA expressive level are also closely related to the formation of cancer.Lung cancer is the disease that threatens the public health,both is incidence and fatality rate are the highest among all cancers,and the persistent dismal prognosis is largely attributable to late diagnosis and treatment.In recent years,investigator have focused on the discovery of early diagnostic methods on cancer,especially on early diagnosis of lung cancer.As a blood tumor marker,MiRNA may be to provide a new important way for the early diagnosis of lung cancer.
出处
《中国医学创新》
CAS
2012年第30期154-156,共3页
Medical Innovation of China
关键词
微小RNA
肺癌
早期诊断
Micro RNA
Lung cancer
Eealy diagnosis
