血浆BNP快速检测对慢性心功能不全的临床诊断价值探讨

Study on the clinical diagnostic value of rapid detection of plasma BNP for chronic heart failure

目的探讨B型钠尿肽(BNP)在慢性心功能不全(CHF)诊断、病情评估方面的临床应用价值。方法选择住院CHF患者160例为CHF组,非CHF患者40例为非CHF组,采用美国Biositer Diagnostics公司的Triage干式快速定量心衰诊断仪,床边抽血检测血浆BNP水平,并行心脏彩超检测患者左室射血分数(LVEF)。结果 CHF组血浆BNP水平高于非CHF组,差异有统计学意义(P<0.01);BNP水平的升高程度与心功能不全的严重程度成正相关,与LVEF成负相关;以BNP>100pg/mL诊断CHF,敏感性为94.4%,特异性为95.0%;CHF患者中,随BNP水平的升高,死亡率升高。结论血浆BNP快速检测对CHF患者的诊断及病情评估具有重要意义。

Objective To study the clinical value of brain natriuretic peptide（BNP） on diagnosis and condition assessment of chronic heart failure（CHF）. Methods One hundred and sixty hospitalized patients with CHF（CHF group） and forty hospitalized patients with non-CHF（non-CHF group） were randomly selected. Plasma BNP and left ventricular ejection fraction（LVEF） were tested in all patients. Results Plasma BNP level in CHF group was higher than that of non-CHF group（P0.01）. Plasma BNP level was positively correlated with the severity of heart failure, and negatively with LVEF. At a cut-off BNP concentration of100 pg/mL, diagnosing sensitivity was 94.4%, and specificity was 95.0%. Patients with high BNP level correlated with higher mortality. Conclusion Rapid detection of BNP had important significance in diagnosis and condition assessment of CHF.