摘要
探讨海参提取物对过度训练大鼠红细胞膜流动性的影响。30只SD大鼠随机分为安静对照组、运动对照组和运动实验组。运动对照组和运动实验组连续运动6周并达到过度训练模型标准。运动实验组每天灌胃海参提取物(标准为45mg/kg),6周后测定观察血常规、红细胞膜流动性相关参数、红细胞SOD及血清MDA指标。结果显示,与运动对照组相比,大鼠经灌胃海参提取物后所测指标均出现良好的改变,其中RBC、Hb、Hct和MCHC均显著高于运动对照组(P<0.01);运动实验组P、η及r值升高的幅度明显减少(P<0.01和P<0.05);SOD的活性却明显升高(P<0.05),DMA的值明显降低(P<0.01)。实验结果提示,海参提取物能有效地抵抗氧化损伤,改善红细胞膜的流动性,对过度训练状态能进行有效的调节。
Aim To study the Effect of sea cucumber extractive on erythrocyte membrane fluidity in rats with overtrai- ning syndrome. Methods: 30 SD rats were divide into three groups as control, exercise c^ntrol and exercise experimental group, The exercise groups were with overtraining syndrome after 6 weeks heavy loads swimming. The experimental group took sea cucumber extractive(45mg/kg) everyday during the 6 weeks, then, test normal blood parameter, parameter of , erythrocyte membrane fluidity and SOD, MDA. Results : The tested parameter showed better change compare with the ex- ercise control group. RBC,Hb、Hct and MCHC were higher (P 〈0. O1 ) ; the value of P,η and r were lower(P 〈0. O1和 P 〈 0.05 ) ; the level of SOD was higher( P 〈 0.05 ), DMA was lower( P 〈 0. O1 ) compare with exercise control group Conclusion Sea cucumber extractive is helpful for antioxidantion, can promote the erythrocyte membrane fluidity and im- prove the overtrainin~ svndrome.
出处
《中华中医药学刊》
CAS
2012年第10期2203-2205,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30970348)
关键词
过度训练
海参提取物
红细胞膜流动性
大鼠
Overtraining syndrome
sea cucumber extractive
Erythrocyte Membrane fluidity
Rats