海参提取物对过度训练大鼠红细胞膜流动性的影响

Effect of Sea Cucumber Extractive on Erythrocyte Membrane Fluidity in Rats with Overtraining Syndrome

探讨海参提取物对过度训练大鼠红细胞膜流动性的影响。30只SD大鼠随机分为安静对照组、运动对照组和运动实验组。运动对照组和运动实验组连续运动6周并达到过度训练模型标准。运动实验组每天灌胃海参提取物(标准为45mg/kg),6周后测定观察血常规、红细胞膜流动性相关参数、红细胞SOD及血清MDA指标。结果显示,与运动对照组相比,大鼠经灌胃海参提取物后所测指标均出现良好的改变,其中RBC、Hb、Hct和MCHC均显著高于运动对照组(P<0.01);运动实验组P、η及r值升高的幅度明显减少(P<0.01和P<0.05);SOD的活性却明显升高(P<0.05),DMA的值明显降低(P<0.01)。实验结果提示,海参提取物能有效地抵抗氧化损伤,改善红细胞膜的流动性,对过度训练状态能进行有效的调节。

Aim To study the Effect of sea cucumber extractive on erythrocyte membrane fluidity in rats with overtrai- ning syndrome. Methods： 30 SD rats were divide into three groups as control, exercise c^ntrol and exercise experimental group, The exercise groups were with overtraining syndrome after 6 weeks heavy loads swimming. The experimental group took sea cucumber extractive（45mg/kg） everyday during the 6 weeks, then, test normal blood parameter, parameter of , erythrocyte membrane fluidity and SOD, MDA. Results ： The tested parameter showed better change compare with the ex- ercise control group. RBC,Hb、Hct and MCHC were higher （P 〈0. O1 ） ; the value of P,η and r were lower（P 〈0. O1和 P 〈 0.05 ） ; the level of SOD was higher（ P 〈 0.05 ）, DMA was lower（ P 〈 0. O1 ） compare with exercise control group Conclusion Sea cucumber extractive is helpful for antioxidantion, can promote the erythrocyte membrane fluidity and im- prove the overtrainin~ svndrome.