复发性口腔溃疡中医分型与临床因素的相关性研究

Relationship between TCM Syndrome Types and Clinical Factors in Patients with Recurrent Oral Ulcer

目的:探讨复发性口腔溃疡3种中医证型与免疫指标、血清微量元素、病程、饮食、便秘、失眠等临床因素的相关性。方法:对50例复发性口腔溃疡患者根据中医辨证分为心脾积热型、阴虚火旺型、气血亏虚型3组,检测患者的血清免疫球蛋白、血清补体及血清铁等指标,同时调查患者的病程、饮食习惯、有无失眠、有无便秘等情况,分析相关因素在3种中医证型的复发性口腔溃疡患者之间的差异性。结果 :复发性口腔溃疡气血亏虚组患者病程明显长于心脾积热组及阴虚火旺组(P﹤0.05);心脾积热组患者血清IgA水平明显高于阴虚火旺组及气血亏虚组(P﹤0.05);心脾积热组患者血清C3水平明显低于气血亏虚组(P﹤0.05);气血亏虚组患者血清Fe离子水平明显低于心脾积热组(P﹤0.05);心脾积热组及阴虚火旺组患者饮食失调情况较气血亏虚组明显严重(P﹤0.05);心脾积热组患者便秘病例数明显多于阴虚火旺组及气血亏虚组(P﹤0.05);3组患者血清IgG、IgM、C4水平无明显差异;3组患者失眠病例数相比无明显差异(P=0.282)。结论:3种中医证型的复发性口腔溃疡患者在病程、血清IgA、C3、Fe、饮食习惯、便秘史等方面存在差异性。

Objective：To analyze the relationship between three TCM syndromes of recurrent oral ulcers with clinical factors such as eating habits, sleep quality, constipation, serum immunogtobulin, serum complement, serum iron. Methods ： According to TCM syndrome differentiation, fifty patients with recurrent oral ulcers were assigned to three groups ： syn- drome of heat retention of heart and spleen, syndrome of hyperactivity of fire due to yin deficiency, and syndrome of defi- ciency of both qi and blood. Each patient was required to fulfill a questionnaire about eating habits, sleep quality and con- stipation. Meanwhile, blood test such as serum immunoglobulin, serum Complement, the serum iron was conducted in all the subjects. Results ：The course of the disease in patients with recurrent oral ulcers in the syndrome of deficiency of both qi and blood group was significantly longer than that the other two groups （P 〈 0.05 ） ;the serum levels of IgA in syndrome of heat retention of heart and spleen group were higher than those in syndrome of hyperactivity of fire due to yin deficiency group （ P 〈 O. 05 ）, and syndrome of deficiency of both qi and blood group （ P 〈 0.05 ） ; the serum complement - 3 （ C3 ） lev- els in syndrome of heat retention of heart and spleen group were notably lower than that in syndrome of deficiency of bothqi and blood group（P 〈0.05） ;the serum iron levels in syndrome of deficiency of both qi and blood group were signifi- cantly lower than that in syndrome of heat retention of heart and spleen group （ P 〈 0.05 ） ; there were more eating disorder patients in syndrome of heat retention of heart and spleen group and syndrome of hyperactivity of fire due to yin deficiency group than syndrome of deficiency of both qi and blood group （ P 〈 O. 05 ） ; there were more constipation patients in syn- drome of heat retention of heart and spleen group than syndrome of hyperactivity of fire due to yin deficiency group and syndrome of deficiency of both qi and blood group （ P 〈 O. 05 ）. Conclusions ： The three TCM syndrome types of recurrent o- ral ulcers differ in course of disease, eating habits, constipation and serum levels of IgA, C3 and iron.