血清降钙素原在脓毒症患儿中的应用价值分析

Application Value Analysis of Detecting Serum Procalcitonin Levels in Sepsis Children

目的:探讨脓毒症患儿血清降钙素原(PCT)水平变化及临床应用价值。方法:对脓毒症组38例患儿(严重脓毒症组16例、非严重脓毒症组22例)血清PCT、C反应蛋白(CRP)水平和白细胞(WBC)计数等指标进行检测,并与非脓毒症组的40例患儿进行比较分析。结果:脓毒症组患儿血清PCT、CRP水平及WBC计数均显著高于非脓毒症组,差异具有统计学意义(P<0.05);血清PCT、CRP水平对诊断脓毒症的敏感性差异无显著性(P>0.05),均显著高于WBC计数,差异具有统计学意义(P<0.05);血清PCT水平特异性、阳性预测值、阴性预测值及约登指数均显著高于CRP和WBC计数,差异具有统计学意义(P<0.05);严重脓毒症组患儿血清PCT水平显著高于非严重脓毒症组,差异具有统计学意义(P<0.05),而两组间血清CRP水平及WBC计数差异不显著(P>0.05)。结论:PCT可作为敏感性的鉴别诊断患儿脓毒症的血清学指标,其效果优于CRP和WBC计数。

Objective： To explore the clinical significance of detecting the serum procalcitonin（PCT） level in children with sepsis.Methods： The serum PCT levels,C-reactive protein（CRP） levels and white blood cell（WBC） count were detected in 38 patients（16 chil-dren with severe sepsis,22 children with non-severe sepsis）,and compared with 40 children without sepsis.Results： The serum PCT lev-els,CRP and WBC count in the sepsis group were significantly higher than non-sepsis group,the difference was statistically significant（P0.05）.The sensitivity of PCT,CRP in the diagnosis of sepsis wasn＇t statistically significant（P0.05）,but it was significantly higher than WBC count,the difference was statistically significant（P0.05）.The specificity,positive predictive value,negative predictive value,Youden index of PCT were significantly higher than CRP and WBC count,the difference was statistically significant（P0.05）;The serum PCT level in the severe sepsis group was significantly higher than that non-severe sepsis group,the difference was statistically signifi-cant（P0.05）,but the serum levels of CRP and WBC count had no significant difference between the two groups（P0.05）.Conclusions： PCT could be used as a sensitive serum marker in diagnosing sepsis in children.The effect of PCT is superior to CRP and WBC count.