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抗胰腺星状细胞药物研究进展 被引量：2

Advances in Pharmacological Agents Aimed at Preventing Pancreatic Stellate Cell Activation
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摘要 慢性胰腺炎传统治疗方法效果不确定,需要寻找新型有效药物。活化的胰腺星状细胞在胰腺纤维化过程中起了重要的作用,使之成为新的治疗靶点。活化PSC的物质分为三类,即炎症介质、氧化应激和毒素。本文就近年来针对以上不同活化PSC的介质和相关通路的抗星状细胞药物进行综述。 The efficacy of current treatment of chronic pancreatitis is poor.With the discovery of pancreatic stellate cell（PSC） and some understanding of the molecular mediators and pathways involved in the pathogenesis of chronic pancreatitis（CP）,inhibition of the activation and functions of PSC has become a potential goal directed to the treatment and prevention of pancreatic inflammation and fibrosis.This review summarizes the current literature addressing the role of different pharmacological agents aimed at preventing activa-tion of PSC.
作者 杨丽娟 王兴鹏
机构地区 上海交通大学附属第一人民医院消化科 同济大学附属第十人民医院消化科
出处 《现代生物医学进展》 CAS 2012年第25期4981-4984,共4页 Progress in Modern Biomedicine
关键词 慢性胰腺炎 纤维化 胰腺星状细胞 Chronic pancreatitis Fibrosis Pancreatic stellate cells
分类号 R735.9 [医药卫生—肿瘤]
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  • 1Apte MV, Haber PS, Applegate TL, Norton ID, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Periacinar stellate shaped cells in rat pancreas: Identification, isolation and culture. Gut 1998, 43:128-133.
  • 2Bachem MG, Schneider E, Gross H, Weidenbach H, Schmidt RM, Menke A, Siech M, Beger H, Grunert A, Adler G.Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998, 115:421-432.
  • 3Haber PS, Keogh GW, Apte MV, Moran CS, Stewart NL,Crawford DH, Pirola RC, McCaughan GW, Ramm GA, Wilson JS. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol 1999, 155:1087-1095.
  • 4Masamune A, Kikuta K, Satoh M, Sakai Y, Satoh A, Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. J Biol Chem 2002, 277:141-147.
  • 5Masamune A, Sakai Y, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro. Pancreas 2002, 25:78-85.
  • 6Masamune A, Satoh M, Kikuta K, Sakai Y, Satoh A, Shimosegawa T. Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells. J Pharmacol Exp Ther 2003, 304:8-14.
  • 7Masamune A, Kikuta K, Satoh M, Satoh K, Shimosegawa T.Rho kinase inhibitors block activation of pancreatic stellate cells. Br J Pharmacol 2003, 140:1292-1302.
  • 8Masamune A, Kikuta K, Masamune A, Kikuta K, Suzuki N,Satoh M, Satoh K, Shimosegawa T. A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells. J Pharmacol Exp Ther 2004, 310:520-527.
  • 9Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis. Gut 1999, 44:534-541.
  • 10Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, Grunert A, Bachem MG. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreatic fibrosis. Lab Invest 2000, 80:47-55.

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现代生物医学进展
2012年 第25期

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