摘要
尼美舒利具有强大的抗炎、镇痛和解热作用。临床主要用于急慢性疼痛、关节炎、月经痛、癌症疼痛和解热。其作用机理主要是通过选择性抑制COX-2而抑制前列腺素的合成。尼美舒利的不良反应与其他NSAIDs相似,但对胃肠道副作用较少。本文总结了尼美舒利的主要临床应用及不良反应。
Nimesulide has strong anti-inflammatory,analgesic and antipyretic effects.Clinically,it is the principal treatment in various acute and chronic pain conditions,joint infiammation in osteoarthritis,dysmenorrhoea,cancer pain,and anti-pyretic.Its mode of action in these states is related to the preferential inhibition of the production of cyclo-oxygenase-2（COX-2）.The adverse reaction profile of nimesulide is like that of other NSAIDs.However,Nimesulide has a relatively low incidence of gastrointestinal（GI） side effects.This review summarized the principal clinical applications and adverse reaction of nimesulide.
出处
《现代生物医学进展》
CAS
2012年第25期4995-4997,共3页
Progress in Modern Biomedicine
基金
广东省建设中医药强省科研课题(2009248)
