川芎嗪、肝素治疗新生儿硬肿症临床研究

Study the effect of Ligustrazine and Heparin on sclerema neonatorum

目的 :研究川芎嗪、肝素治疗新生儿硬肿症的临床疗效。方法 :对 10 5例新生儿硬肿症随机分成对照组 53例 ,给予综合疗法 :观察组 52例 ,在综合疗法的基础上给予川芎嗪 ,对中、重度硬肿症加用肝素。结果 :观察组与对照组复温时间 ( h)分别为 11.6± 3.5,2 0 .0 9± 4 .3;平均硬肿消退时间 ( d)为 2 .70± 1.68,4 .50± 1.98;平均住院日数 11.38± 3.17,14.86± 3.5;显效率 4 8.0 8% ,2 2 .64% ;死亡率 1.92 % ,5.66% ;经统计学处理 P值均 <0 .0 1。结论 :观察组复温时间、硬肿消退时间、住院日数较对照组明显缩短 ,显效率明显高于对照组 ,死亡率明显低于对照组。

Objective:[WT5BZ]To evaluate the effect of Ligustrazine (L)and Heparin(H)on Sclerema neonatorum.[WT5HZ]Method:[WT5BZ]105 cases of sclerema neonatorums divided into 2 groups randomly,the L.H group(52 cases )and control group (53 cases).The patients in control group were treated by routine therapy and in L.H group were treated by Ligustrazine ,Heparin for modera and severe sclerema based on routine therapy.[WT5HZ]Results:[WT5BZ] 52 cases in L.H group and 53 cases in control group,the rewarming time ,average seleroderma repercussive time ,average date in hospital were 11.6±3.5(h)vs,20.09±4.3(h),2.70±1.68(d)vs,4.50±1.98(d).11.38±3.17(d)vs,11.86±3.5(d).The effectiveness rates were 48.08%vs22.64%.The death rates were 5.66% vs.1.92%.(P<0.01).[WT5HZ]Conclusion:[WT5BZ]In L/H group,the rewarming time ,scleroderma repercussive time and date in hospital were significantly shorter than that in control group,The effectiveness in L.H group was significantly higher than that in control group.The mortality rate in L.H group was significantly lower than that in control group. [WT5HZ]