糖尿病尿五种微量蛋白检测评估早期肾损害

Value of testing 5 trace proteins in urine to the evaluation of early kidney damage in diabetes

目的 :探讨尿五种微量蛋白测定在糖尿病肾病 ( DN)早期诊断中的临床价值。方法 :采用放射免疫分析法 ( RIA)检测 30例正常人及 98例非胰岛素依赖性糖尿病 ( NIDDM)患者尿液 :α1 —微球蛋白 ( α1 — MG)、β2 —微球蛋白 ( β2 —MG)、Tamm- Horsfall蛋白 ( THP)、白蛋白 ( ALb)及免疫球蛋白G( Ig G)含量。结果 :随着 CCr值的下降 ,尿 α1 —MG、β2 — MG、ALb及 Ig G排泄量逐渐增高 ,而尿 THP排泄量逐渐下降。结论 :尿五种微量蛋白测定为糖尿病 ( DM)早期肾损伤诊断敏感指标。

Objective:[WT5BZ]To probe the value of testing 5 trace proteins in urine to the diagnosing of early kidney damage in patients with diabetes nephropathy(DN).[WT5HZ]Method:[WT5BZ]Testing 5 trace proteins-α 1—microglobulin (α 1—MG),β 2—microglobulin (β 2—MG),Tamm-Horsfall protein (THP),albumin (ALb) and immunoglobulin G (IgG)-in urine of 30 normal persons and 98 non-insulin depending diabetics (NIDDM) by RIA.[WT5HZ]Result:[WT5BZ]The excreting of α 1—MG,β 2—MG、ALb and IgG increases while THP decreases in urine with the decrease of CCr.[WT5HZ]Conclusion:[WT5BZ]The testing of 5 trace proteins in urine is of usage for indicating kidney damage early in patients with DM. [WT5HZ]