紫绀型与非紫绀型先天性心脏病患儿吸入麻醉药血/气分配系数

Blood/Gas Partition Coefficients of Volatile Anesthetics in Children with Congenital Heart Disease

目的 :测定并比较紫绀型与非紫绀型先天性心脏病患儿吸入麻醉药血 /气分配系数 (B/G) ,判断红细胞压积 (Hct)对B/G的影响。方法 :紫绀型与非紫绀型先天性心脏病患儿各 10例 ,平均年龄 5岁 ,采桡动脉血 10ml,用两次平衡法测定地氟醚、异氟醚和氟烷的B/G ,并测定血浆总胆固醇、甘油三脂、白蛋白、球蛋白浓度和Hct,t检验比较两组间血液成分和吸入麻醉药B/G有无差别。结果 :紫绀型与非紫绀型先天性心脏病患儿Hct有显著差异 (紫绀型为 6 8 7%± 11 1% ,非紫绀型 37 7%± 2 9% ,P <0 0 5 ) ;但两组间其他血浆成分和三种吸入麻醉药的B/G无差异 (P>0 0 5 )。结论 :Hct对B/G无影响 。

Objective:To determine and compare the blood/gas partition coefficients(B/G) of volatile anesthetics in children with cyanotic or acyanotic congenital heart disease.Methods:Blood samples were obtained from two groups of fasting children aged about 5 years old.B/G of desflurane,isoflurane and halothane in each subject was measured by double equilibration technique.Blood hematocrit and the serum concentrations of cholesterol,triglyceride,albumin,globulin were measured.Results:Hematocrit was significantly different between the two groups(cyanosed 68 7%±11 1%,cyanotic 37 7%±2 9%, P< 0 05),but the concentration of the serum constituents and B/G of the three volatile anesthetics were not different between the two groups( P> 0 05).Conclusion:Hct has no effect on B/G.B/G values of volatile anesthetics are the same between children with cyanotic and acyanotic congenital heart diseases.