低血容量休克时血浆一氧化氮及儿茶酚胺的变化

The Changes and Implication of SerumNitric Oxideand Catecholaminein Hemorrhagic Shock Rabbits

目的 :观察兔失血性休克时一氧化氮 (NO)、去甲肾上腺素 (NE)和肾上腺素 (E)的变化及其在休克发展中的作用。方法 :2 4只家兔随机分为休克组和对照组 ,每组 12只。休克组经股动脉放血至MAP达 6 6 7kPa,维持 30分钟后于 0 5、1、3及 6小时采血 ,测定NO-2 、NE和E的水平 ,对照组于相应时点采血测定上述指标。结果 :休克组在实验后各时点的NO-2 、NE及E水平均较实验前及对照组相应时段明显升高 (P <0 0 5 )。结论 :休克时NO生成增加 ,使血管进一步扩张 ,加重休克 ;NO降低了血管对儿茶酚胺的缩血管反应 。

Objective:Tostudythechangesofnitricoxide(NO) ,epinephrine(E)andnorepinephrine (NE)andtheiref fectsonthedevelopmentofshock .Methods :Twenty fourrabbitsweredividedinto 2groups :Shockgroup(n =12 )andcon trolgroup (n =12 ) .Theshockstate (MAP =6 6 7kPa)wasinducedbycontrolledbleedingandmaintainedfor 30min .Blood samplesweredrawnat 0 5 ,1,3and 6hourformeasurementsofNO-2 ,EandNE .Incontrolgroup ,thebloodsampleswere takenandmeasuredatthecorrespondingintervals.Results:Aftershock ,thelevelofNO-2 ,EandNEateachtime pointwas obviouslyhigherinshockgroupthanthatofpreshockandcontrolgroup (P <0 0 5 ) .Conclusion :Inshockstate ,thelevelof NOisincreased ,resultinginvaso dilationanddecreasesensitivityofvesseltocatecholamines.