缺血性预适应对急性心肌梗死范围及左室功能的影响

Influence of ischemic precondition on myocardial infarction range and left ventricular function

目的 :利用回顾性调查方法分析梗死前 48h内发生心绞痛对梗死范围和左室功能的影响 ;方法 :比较AP组和无AP组梗死范围、血清CPK、左室舒张末期内径、LVEF、严重心律失常和 4周病死率的异同 ;结果 :AP组Q波性心梗显著低于无AP组(80 6 6 %VS1 0 0 % ,P <0 0 5 )。CPK峰值和左室舒张末期内径显著低于无AP组 ,而LVEF明显高于无AP组。两组合并严重心律失常及 4周病死率方面无显著性差别 ;结论 :梗前心绞痛能保护心肌和改善左室功能 ,其机制可能与缺血预适应有关。

Objective:Analysis of preinfarction angina on infarction range and left ventricular function with retrospective study;Methods:comparing the difference of infarction range,serum CPK,left ventricular diastasis internals path,LVEF,severity arrhythmia,4 week fatality rate between AP and no AP group;Results:Q wave MI in AP group is significant lower than no AP group(80.66% vs 100%,P<0.05),CPK peak and left ventricle diastasis internals path in AP group is striking lower than no AP group.LVEF in AP group obviously higher than no AP group.But no difference between severity arrhythmia and 4 weeks fatality rate;Conclusion:preinfarction angina can protect myocardium and improve left ventricle function as ischemia beforehand adaption. [