574例结核病化疗分析

Analysis of chemotherapy in 574 tuberculosis cases

目的 :为临床抗结核药的合理应用提供有益的参考依据。方法 :分析 5 74例结核病人 ,1 2种抗痨药组成的不同化疗方案的疗效。结果 :1 2种抗痨药使用频率依次为异烟肼 (H)、利福平 (R)、链霉素 (S)、吡嗪酰胺 (Z)、乙胺丁醇 (E)、PAS(P)、丙硫异烟胺 (T)、丁胺卡那 (A)、利福喷丁 (D)、力克肺疾 (Pa)、环丙沙星 (C) 氧氟沙星 (O)、卷曲霉素 (C)。常用方案 4种 ,HRSZ(332例 )、HRSZP(86例 )、HRSZE(2 2例 )、HRTCA(1 4例 )。结论 :4药联用最多 (6 3 1 % ) ,总有效率 89 0 % ,5药联用者排第 2 (2 3 0 % ) ,总有效率 87 7%。HRTCA方案对难治复治结核疗效较好。

Objective:Provide basis for clinic tuberculosis chemotherapy.Methods:In 574 cases of tuberculosis,curative effect of differen chemotherapy plan composed of twelve kinds tuberculocidal drugs was analysed.Results:used freguency of twelve kinds of tuberculocidal drugs from high to low was INH(H)、RFP(R)、SM(S)、PZA(Z)、EMB(E)、1321Th(T)、Amikacin(A)、RFT(D)、Dipasic(Pa)、Ciprofloxcin(C)、ofloxacin(O)、CPM(C).Four plans were used usually,they were HRSZ(332 cases)、HRSZP(86 cases)、HRSZE(22 cases)、HRTCA(14 cases).Conclusion:the most used plan was that four drugs combined(63.1%),total effective rate was 89.0%,the second was five drugs combined,total effective rate was 87.7%.HRTCA Plan is good to patiens which were difficult to cure and to those needing repeat treatment. [